Induction of Rat Hepatic Cytochromes P450 Ingredients in Plants: Lack of Correlation Toxicity and Inductive Activity by Toxic Between

was given to rats for 4 days, and the hepatic activity of testosterone metabolism was detennined together with monitoring body weight gain and liver weight as the indices of toxicity. The results showed that while cocaine and nicotine have a minor ability to increase t stosterone 16i? -hydroxylase activity, a marker activity for the CYP2B 1 and 2, a]1 other compounds did not have any such eilect, No correlation was observed betwcen a cltange in 16s3-hydroxylase and toxicity caused by toxins, Therefore, these results did not support the idea that the inducibility of the CYP2B subfamily in animals is acquired through "Animal